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Type 1 Diabetes & Stem Cells

[et_pb_section bb_built=”1″ fullwidth=”off” specialty=”off” _builder_version=”3.0.92″][et_pb_row][et_pb_column type=”4_4″][et_pb_text _builder_version=”3.0.92″ background_layout=”light”] The old paradigm was, “Diabetes type 1 is an irreversible short-term autoimmune disease that destroys all of the insulin-producing cells in the pancreas.”[1] However, Dr. Neil H. Riordan has proposed a new paradigm, “Diabetes type 1 is a chronic autoimmune disease that, when corrected, allows the insulin-producing cells of the pancreas to regenerate.” In 2010, researchers injected type-1 diabetic mice in the abdomen with pig Sertoli cells.[2] Sertoli cells are similar to stem cells and are oftentimes called nurse cells because they nourish and protect other cells. Although Sertoli cells do not secrete insulin, 81% of the diabetic mice became non-diabetic from a single injection.[3] The reason the mice became non-diabetic was the Sertoli cells secreted immune-modulating molecules and the damaged pancreatic cells were able to regenerate. The regenerated pancreatic cells made all the insulin the mice needed to be healthy. [/et_pb_text][et_pb_image _builder_version=”3.0.92″ src=”https://secureservercdn.net/198.71.233.179/ovd.0e3.myftpupload.com/wp-content/uploads/2018/05/type-1-diabetes-and-stem-cells.jpg” show_in_lightbox=”on” url_new_window=”off” use_overlay=”off” always_center_on_mobile=”on” force_fullwidth=”off” show_bottom_space=”on” /][et_pb_text _builder_version=”3.0.92″ background_layout=”light”] Typically, tissues and organs that are transplanted from one person to another require life-long immunosuppressive therapy with drugs or surgery.[4] Otherwise, your immune system will recognize that the newly introduced tissue is not your own and will attack it. Stem cells have a special ability to calm the immune system and reduce inflammation, especially placenta and umbilical stem cells.[5] The rationale of using stem cells for type 1 diabetes is because of these special immune privileges. Clinical trials investigating stem cells for type 1 diabetes have been conducted since 2005.[6] Collectively, these studies demonstrate that stem cell therapy can improve insulin production, laboratory parameters and chronic complications of diabetes.[7] In addition, stem cell treatment has made 20 to 60% of type 1 diabetic patients insulin-free depending on the type of stem cells used for periods as long as 12 to 24 months.[8] Administration of stem cells early after type 1 diabetes diagnosis was more effective than treatment at later stages. Thus far studies conclude, stem cell therapy has been shown to be safe and generally considered cost-effective. Ongoing clinical trials are being carried out for type 1 diabetes to determine the efficacy of different doses, stem cell mobilizers and stem cell sources including placenta and umbilical tissues.[9-12] [/et_pb_text][/et_pb_column][/et_pb_row][et_pb_row][et_pb_column type=”4_4″][et_pb_text _builder_version=”3.0.92″ background_layout=”light”]

References

  1. Riordan, N.H., Stem Cell Therapy: A Rising Tide: How Stem Cells Are Disrupting Medicine and Transforming Lives. 2017: Neil H Riordan.
  2. Luca, G., et al., Xenograft of microencapsulated sertoli cells reverses T1DM in NOD mice by inducing neogenesis of beta-cells. Transplantation, 2010. 90(12): p. 1352-1357.
  3. Mital, P., G. Kaur, and J.M. Dufour, Immunoprotective sertoli cells: making allogeneic and xenogeneic transplantation feasible. Reproduction, 2010. 139(3): p. 495-504.
  4. Medscape. Immunosuppression: Overview. 1/4/2016 [Date Accessed: 1/2018]; Available from: https://emedicine.medscape.com/article/432316-overview.
  5. Lovell, T.M., et al., Identification of a novel mammalian post-translational modification, phosphocholine, on placental secretory polypeptides. J Mol Endocrinol, 2007. 39(3): p. 189-98.
  6. Lock, L.T. and E.S. Tzanakakis, Stem/Progenitor cell sources of insulin-producing cells for the treatment of diabetes. Tissue engineering, 2007. 13(7): p. 1399-1412.
  7. Madani, S., et al., Safety and efficacy of hematopoietic and mesanchymal stem cell therapy for treatment of T1DM: a systematic review and meta-analysis protocol. Systematic reviews, 2018. 7(1): p. 23.
  8. El-Badawy, A. and N. El-Badri, Clinical efficacy of stem cell therapy for diabetes mellitus: a meta-analysis. PLoS One, 2016. 11(4): p. e0151938.
  9. ClinicalTrials.gov. Umbilical Mesenchymal Stem Cells and Mononuclear Cells Infusion in Type 1 Diabetes Mellitus. [Date Accessed: 5/2018]; Available from: https://clinicaltrials.gov/ct2/show/NCT01374854.
  10. ClinicalTrials.gov. Use of Stem Cells in Diabetes Mellitus Type 1. [Date Accessed: 5/2018]; Available from: https://clinicaltrials.gov/ct2/show/NCT02940418.
  11. ClinicalTrials.gov. Stem Cell Mobilization (Plerixafor) and Immunologic Reset in Type 1 Diabetes (T1DM). [Date Accessed: 5/2018]; Available from: https://clinicaltrials.gov/ct2/show/NCT03182426.
  12. ClinicalTrials.gov. Mesenchymal Stem Cells to Intervene in the Development of Type 1 Diabetes: a Blinded Randomized Study. [Date Accessed: 5/2018]; Available from: https://clinicaltrials.gov/ct2/show/NCT02057211?term=stem+cells&cond=Type+1+Diabetes&rank=7.
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1 Comment

  1. Wiki on May 21, 2018 at 8:22 pm

    Hello ,

    I saw your tweet about animals and thought I will check your website. I like it!

    I love pets. I have two beautiful thai cats called Tammy(female) and Yommo(male). Yommo is 1 year older than Tommy. He acts like a bigger brother for her. 🙂
    I have even created an Instagram account for them ( https://www.instagram.com/tayo_home/ ) and probably soon they will have more followers than me (kinda funny).

    I wanted to subscribe to your newsletter, but I couldn’t find it. Do you have it?

    Keep up the good work on your blog.

    Regards
    Wiki